Ccris 8657
Obacunone
CAS: 751-03-1
Molecular Formula: C26H30O7
Ccris 8657 - Names and Identifiers
Ccris 8657 - Physico-chemical Properties
| Molecular Formula | C26H30O7 |
| Molar Mass | 454.51 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 229～230℃ |
| Boling Point | 626.2±55.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)-50 |
| Flash Point | 361.2°C |
| Solubility | Insoluble in water, soluble in chloroform, acetone, glacial acetic acid, insoluble in ether, slightly soluble in ethanol. |
| Vapor Presure | 4.54E-19mmHg at 25°C |
| Appearance | Colorless crystal |
| Storage Condition | 2-8°C |
| Refractive Index | 1.614 |
| MDL | MFCD00075888 |
| Physical and Chemical Properties | Soluble in ethyl acetate, acetone, DMSO and other solvents, insoluble in water. From Phellodendron chinense, a plant of Rutaceae |
Ccris 8657 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | RR1104200 |
| HS Code | 29322090 |
Ccris 8657 - Reference
| Reference Show more | 1. Zhou Lili, Zuo, Ling, Ma Donglei. Determination and cluster analysis of the content of the content of the white fresh skin in different areas [J]. Journal of Hebei North University (Natural Science Edition) 2012 28(1):12-14. 2. Zhou Lili, Zuo Ling, Ma Donglei, etc. Comparative study on active components of White fresh root bark and wood core [J]. Journal of Chongqing University of Arts and Science (Social Science Edition), 2013, 32(3):63-65. 3. Li Dongyao, Chen Wenjie, Shang Jun, etc. Inhibitory effect of berberine on intimal hyperplasia after autogenous vein graft in rats and its mechanism [J]. Guangxi Medical Journal, 2018(7):808-811. 4. [IF = 11.878] Li Xinming et al."A fast and specific fluorecent probe for thioredoxin reductase that works via disculide bond cleavage. Nat Commun. 2019 Jun;10(1):1-12 5. [IF = 2.408] Wei Ling et al."Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components."Chemistry & Biodiversity. 2021 Oct 27 |
Ccris 8657 - Reference Information
| plant origin | 1. Main source-cortex phellodendri: The original name of Aralia was published in Shen Nong's natural classic of grass, which is listed as top grade. "Chinese Pharmacopoeia" 1963 edition of a collection in Phellodendron. Due to the yellow bark, it is named Phellodendron amurense. Alias guanbai, Aralia, Phellodendron amurense, bark, Sabina vaginalis. cortex phellodendri is the dried bark of the yellow-bark tree, phellodendronchinen schneid. Or Phellodendron phellodronamurenserupr. The former is called "Phellodendron chinense", and the latter is called "Phellodendron chinense". cortex phellodendri is mainly produced in Sichuan, Guizhou and other provinces, Shaanxi, Hubei, Yunnan, Hunan, Gansu, Guangxi and other provinces. Phellodendron amurense is mainly produced in Jilin, Liaoning and other provinces. Inner Mongolia, Hebei, Heilongjiang and other provinces also produced. Remove the coarse skin to yellow, and dry to semi-dry in the sun, overlap into a stack, flatten with a stone plate, and then dry in the sun. Quality specifications to dry, bright yellow, thick skin to clean, skin thickness is better. Figure 2 is the original plant and medicinal materials of cortex phellodendri The main chemical components of cortex phellodendri are: Alkaloids-Berberine (Berber), magnolin (Magnoflorine), Phellodendrine (Phellodendrine) jatrorrhizine, palmar Tetrandrine (Palmatine), etc.; Esters-Phellodendron lactone (Obaculactone), Phellodendron ketone (Obacunone), White fresh lactide (Dictamnolide); Organic acids; Sterols. chemical characterization of Phellodendron chinense: Take 1g of this product powder, Add 10ml of ether, shake and filter, volatilize the filtrate to dryness, add 1mL of glacial acetic acid to dissolve the residue, and add 1 drop of hydrochloric acid, the solution was purple-brown. (Check for flavanone and sterols). 2. Other sources: cortex phellodendrine phellodendri phellodendri cortex phellodendri. Stem bark P.molleNakai stem bark pomelo citrusgranis (L.) osbeck seed C.medicaL. Fruit Coptis chinensis Coptis chinensis (Coptis chinensis) Franch. HarrisoniaabyssinicaOliver, a plant of the bitter Wood family. |
| separation and extraction | the optimum extraction process of Phellodendron amurense ketone from White fresh skin was as follows: Extracting twice with 8 times the amount of 95% ethanol, 1h every time. According to the optimized extraction process, the extraction rate was 4.192mg/g. |
| determination of content | high performance liquid chromatography, column Agilent C18(150nm × 4.6nm,5 μm), the mobile phase was Methanol-Water (60: 40); The flow rate was 0.8ml/min; The column temperature was 25 ℃; The detection wavelength was 212nm. The range of content of Phellodendron amurense in different areas was 2.41-3.01mg/g. Figure 3 is the liquid chromatogram of White fresh skin sample White fresh skin has a wide range of applications in traditional Chinese medicine, in 2010, the Pharmacopoeia of the People's Republic of China added the reference substance for the determination of the content of the chemical constituents of the white fresh bark, and the Pharmacopoeia of the People's Republic of China added the item of [content determination] under the item of "white fresh bark, provisions of the white fresh skin medicinal materials" this product according to the calculation of the dry product, containing not less than 0.15%. there are some differences in the content of Phellodendron amurense in different habitats. The results of content determination and cluster analysis showed that the content of Phellodendron amurense in Inner Mongolia was the highest and was divided into one group separately, anhui was divided in a group; Liaoning, Heilongjiang, Jilin were divided in a group; Shaanxi, Shandong, the lowest, were divided in another group. |
| pharmacological action | 1. Efficacy of cortex phellodendri: cortex phellodendri is bitter and cold. It belongs to kidney, bladder and large intestine. Fire detoxification strong, good governance of damp heat diarrhea, sore, jaundice, bring down, hot shower, beriberi, etc. Spleen and stomach deficiency cold should not be used. 2. Modern pharmacological research 1. Cause the insect to produce the antifeeding behavior 2. Microtubule inhibition potentiation: enhances the cytotoxicity of antineoplastic agents (e. G., vincristine, vinblastine, and paclitaxel) that have a microtubule-inhibiting effect, which itself has no cytotoxicity. However, there is no obvious synergistic effect on other antitumor drugs such as RNA synthesis inhibitors, alkylating agent factors, thymidylate synthase inhibitors and the like. 3. Neuroprotective activity: methanol extract of White fresh root bark has neuroprotective effect. The ethanol extracts, including the one, exhibited strong neuroprotective activity (against glutamate-induced neurotoxicity) against primary cultured rat cortical cells at a concentration of 0.1 μmol/L. 4. Limonin analogs have antitumor, insect Antifeedant, antiviral, analgesic, anti-inflammatory, hypnotic and other biological activities. |
| Microbial transformation | Microbial transformation refers to the use of enzymes produced in the process of microbial metabolism to catalyze a substrate for a chemical reaction. Microbial transformation has been applied to the synthesis of a variety of drugs. In recent years, Microbial transformation of natural products has become an auxiliary means of structural modification, and it is also a method of obtaining new compounds to screen bioactive compounds. In this paper, the transformation experiment of Chrysotile was carried out by Aspergillus Niger and other fungi. The results showed that when the culture temperature was lower than 30 ℃, the Phyllanthus emblica could catalyze the transformation of the structure of phellodendrone, and the C- 11th position was hydroxylated. The fermentation broth containing the conversion product was extracted with ethyl acetate, the compound was separated by silica gel column chromatography to obtain zapoterin. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: with fever, dysentery, and can enhance the cytotoxic effect of antitumor drugs. |
Last Update：2024-04-09 19:05:15
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Obacunone Visit Supplier Webpage Request for quotationCAS: 751-03-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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